polymorphism vs mutation

It's something that happens and changes a genome, usually they go unnoticed, sometimes they cause a disease and very rarely they might give a selective advantage and alter evolution. I have a large number of protein sequences of Homo sapiens. )), is heritable but is not necessarily harmful to the host. Even variants that are quite often can cause the clinical phenotype (thing of lactose intolerance). I largely agree with the distinction finswimmer made, that's also how my "field" generally uses these terms. It's not clear whether this is what OP is asking (question is very open).

Mutations don't always have a strong negative effect, and such mutations (or changes) in DNA sequence can remain in the population. I don't think the source of the genomic change (so exogenous or endogenous) has something to do with it.Hope it helpsDavid, A polymorphism is a mutation that has been proven to have a prevelance above a certain % in a given population. But there's a problem with this definition. It occurs rarely and some mutations are beneficial and lead to evolution. So whenever possible one should avoid the term "polymorphism" and "mutation". Polymorphism seems to me to be a more general term simply meaning "many forms", as the name implies " poly-morphs". This heritable change will occur in at least 1% of the population.If examples had to be given , which examples will be classified under mutations and which under polymorphism.?

The explanation I've been given is that a mutation causes disease whereas a polymorphism does not. A single-nucleotide polymorphism (SNP, pronounced snip) is a DNA sequence variation occurring when a single nucleotide adenine (A), thymine (T), cytosine (C), or guanine (G]) in the genome (or other shared sequence) differs between members of a species or paired chromosomes in an individual. I don't think I've heard anyone in my microbiology group use "SNV"! And we have lot variants we know nothing/not enough about whether they causes the clinical phenotype. A polymorphism is a variation that exists in or becomes fixated within a population, e.g. This is quite a basic (yet, thought-provoking...) question, as if it were just taken from an assignment / exam. As with mutations they might go unnoticed, but they usually have small effects on phenotypes: not as much as mutations. in a nut shell "yes": the key point is the prevalance in the population, polymorphisms are those found in a significant proportion of the population, whereas mutations are not. In popgen, a mutation is described as a one time single event, while a polymorphism is a mutation that was able to increase in frequency within the population..More precisely, if the frequency of appearance of the "variant" is higher that neutral equilibrium population mutation rate, it is a polymorphism.

If its an INDEL, it gets a little more complicated depending on the "Polymorphism" often means: "This variant have a frequency over 1% in the population, so we don't think it causes the clinical phenotype.". through evolution the cell changes to conform to the changing environment to survive...(after all the basic function of a cell is to use all its various pathways and mechanism to surivive and thereby maintaining its function within the host. Here are my questions that I hope you'd be able to help to elucidate: For example, certainly in the circles I move in academically, "variant" would probably be the vague term and you wouldn't get very far using it. This heritable change will occur in at least 1% of the population.If examples had to be given , which examples will be classified under mutations and which under polymorphism.? Hi 143,Good question.Dictionaries are not clear on this point. As you know, there are some antiretroviral compounds used for treatment of HIV-infected people. the differences depends on the person who uses this terms :) In general a variant is every difference to the given reference..

)), is heritable but is not necessarily harmful to the host. The term "polymorphism" and "mutation" are usually used in a clinical environment. Since all polymorphism has a genetic basis, genetic polymorphism has a particular meaning: Genetic polymorphism is the simultaneous occurrence in the same locality of two or more discontinuous forms in such proportions that the rarest of them cannot be maintained just by recurrent mutation or immigration, originally defined by Ford (1940). but would more likely just refer to it as an SNP (single nucleotide

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