optic neuritis after flu shot

One possible mechanism for this is molecular mimicry, which refers to the possibility that similar epitopes shared between self-peptides and foreign peptides (introduced via infection or immunization) inadvertently cause the activation of autoreactive T or B cells, leading to autoimmunity. Another possible mechanism is activation of the complement system, in which a cascade of proteolysis and successive release of cytokines functions to amplify the immune response but can damage host cells if not properly regulated.

Bacterial and viral infections, including influenza, may cause inflammation of the optic nerve.Unfortunately, neurologists discovered a link between optic neuritis and the vaccine. Because of damage to the optic nerve, flu vaccine injury claims have been filed with a federal Vaccine Injury Compensation Program. His mother took him to a local hospital where a computed tomography brain scan was done and read as normal. The authors described a case of a 6-year-old girl who developed bilateral optic neuritis following inactivated influenza vaccination.A previously healthy 6-year-old developed bilateral retrobulbar optic neuritis 1 week following inactivated influenza vaccination, which was supported by long segment enhancement of both optic nerves on orbital MRI. Those who live with or care for these people should also get vaccinated.Some people should not get a flu vaccination without doctor approval. your express consent. ... 27 The ages of previously reported patients with optic neuritis after vaccination range from 6 to 61 at an interval after immunization of 5 to 21 days. Although an adverse event of optic neuritis is extremely uncommon—estimated at 0.003/100,000 vaccines—clinicians should be aware of this possible clinical presentation, given that the prognosis for visual recovery is good when treated promptly with systemic steroids.A syndrome termed ASIA (autoimmune/inflammatory clinical syndromes induced by adjuvants) was coined in 2011, and describes the potential for vaccine adjuvants (i.e., potentiators) to trigger an exaggerated, hyperactive immune response. It may require hospitalization and can sometimes lead to death. Tan FU, Akarsu C, Gullu R, et al. 20 Reports of vaccine-induced optic neuritis usually include a presentation from days to four weeks following vaccination although there are some reports of optic neuritis up to six … Poser C. Neurological complications of swine flu influenza vaccination.14. The IOM found no relevant studies of quality in the literature assessing optic neuritis and pertussis vaccine or NMO and MMR, influenza, hepatitis B or HPV vaccines [1].Anti-phosphatidylcholine antibodies have been suggested as a potential cause of optic neuritis [10]. He had evidence of myopia, as he needed to come close to objects to see them. The authors suggested a possible association between optic neuritis and prior receipt of the anthrax vaccine, possibly as a result of a potential immune-mediated response to optic nerve antigens that was stimulated by the vaccine. Background Several case reports of the onset or exacerbation of multiple sclerosis or other demyelinating conditions shortly after vaccination have suggested that vaccines may increase the risk of demyelinating diseases..

Approximately three-quarters of cases follow infection or immunization, as an encephalomyelitis. The consensus is that an immune attack develops against CNS myelin.As in our case, most cases involve unilateral or bilateral optic neuropathy or ADEM, rather than simultaneous onset of both conditions. Adverse Effects of Vaccines: Evidence and Causality.Advisory Committee on Childhood Vaccines (ACCV) Meeting.Vaccine Injury Compensation Program Data and Statistics.Post-vaccination encephalomyelitis: literature review and illustrative case.Neurologic complications associated with influenza vaccination: two adult cases.Acute disseminated encephalomyelitis following influenza vaccination.An adverse event following 2009 H1N1 influenza vaccination: a case of acute disseminated encephalomyelitis.Acute disseminated encephalomyelitis following 2009 H1N1 influenza vaccination.Machicado JD, Bhagya-Rao B, Davogustto G, McKelvy BJ.Acute disseminated encephalomyelitis following seasonal influenza vaccination in an elderly patient.Acute disseminated encephalomyelitis following influenza vaccination: report of a case with callosal disconnection syndrome.Acute disseminated encephalomyelitis following inactivated influenza vaccination in the Brazilian Amazon: a case report.Post-infectious and post-vaccinal acute disseminated encephalomyelitis occurring in the same patients.Simultaneous development of acute disseminated encephalomyelitis and Guillain-Barré syndrome associated with H1N1 09 influenza vaccination,Ischemic stroke in a patient with lupus following influenza vaccination: a questionable association.Radial nerve motor palsy following seasonal influenza vaccination: a case report.Acute brachial neuritis following influenza vaccination.Postvaccinial (influenza) disseminated encephalopathy (Brown-Sequard syndrome).Reactive arthritis after influenza vaccination: report of a case.Bullous pemphigoid triggered by swine flu vaccination: case report and review of vaccine triggered pemphigoid.Bullous pemphigoid following influenza vaccination.Fournier B, Descamps V, Bouscarat F, et al.Bullous pemphigoid induced by vaccination.Does influenza vaccination induce bullous pemphigoid?

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